Di tert butyl dicarbonate: an invisible promoter of chemical synthesis

Di tert butyl dicarbonate (BOC) is an important organic reagent, mainly used for:
1. Amino protection
BOC is commonly used to protect the amino group (- NH2), forming BOC protected amine compounds (- NHBOC) to prevent the amino group from being destroyed or side reactions from occurring during the reaction. BOC groups are easily removed under acidic conditions (such as trifluoroacetic acid or hydrochloric acid), restoring free amino groups.
2. Peptide synthesis
In peptide synthesis, BOC is used to protect the amino groups of amino acids, ensure the correct connection of peptide chains, and avoid side reactions. The BOC protecting group can be removed by acid treatment after synthesis.
3. Synthesis of drug intermediates
BOC is used in drug synthesis to prepare intermediates, especially in complex molecular synthesis, to protect amino groups and improve reaction selectivity and yield.
4. Organic synthesis
BOC is widely used in organic synthesis to protect functional groups such as amino and hydroxyl groups, ensuring high efficiency and selectivity of reactions.
5. Research on bioactive molecules
When studying bioactive molecules, BOC is used to protect amino groups, facilitating subsequent modification and functional research.
6. Other applications
BOC can also be used for the synthesis of compounds such as amino esters and tert butyl amino esters, and is widely used in materials science and polymer chemistry.
In summary, the main function of BOC is as an amino protectant, widely used in peptide synthesis, drug intermediate preparation, organic synthesis, and research on bioactive molecules.